LNP Mouse Monoclonal Antibody [11-1] (EM1701-57)

UNIPROT #

Q9C0E8

PROTEIN NAME

LNP

SYNONYMS

lnp antibody;LNP_HUMAN antibody;Protein lunapark antibody;Endoplasmic reticulum junction formation protein lunapark;ER junction formation factor lunapark;LNPK;KIAA1715;LNP

SEQUENCE SIMILARITIES

Belongs to the lunapark family.

TISSUE SPECIFICITY

Expressed in most tissues at basal level, with reinforcement in distal limb buds, genital bud, and in parts of the central nervous system.

DEVELOPMENTAL STAGE

Strongly expressed in both limb and genital buds as is the case for Evx2 and Hoxd genes, in particular Hoxd13. In developing limb buds, it is first seen in 10.5 days old fetuses, in the posterior distal bud, to subsequently extend throughout the distal aspect, in presumptive digits.

POST-TRANSLATIONAL MODIFICATION

Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes.; Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-222, Ser-316 and Ser-380 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-348 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.; Subject to proteasomal degradation following phosphorylation during mitosis.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development (By similarity). Is involved in central nervous system development. Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. Is integral component of endoplasmic reticulum membrane.