LOXL2 Rabbit Polyclonal Antibody (ER1803-41)

UNIPROT #

Q9Y4K0

PROTEIN NAME

LOXL2

SYNONYMS

LOR 2 antibody;LOR2 antibody;LOX L2 antibody;LOXL 2 antibody;LOXL2 antibody;LOXL2_HUMAN antibody;Lysyl oxidase homolog 2 antibody;Lysyl oxidase like 2 antibody;Lysyl oxidase like protein 2 antibody;Lysyl oxidase related 2 antibody;Lysyl oxidase related protein 2 antibody;Lysyl oxidase related protein WS9 14 antibody;Lysyl oxidase-like protein 2 antibody;Lysyl oxidase-related protein 2 antibody;Lysyl oxidase-related protein WS9-14 antibody;WS9 14 antibody

SEQUENCE SIMILARITIES

Belongs to the lysyl oxidase family.

TISSUE SPECIFICITY

Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. In esophageal epithelium, expressed in the basal, prickle and granular cell layers. Up-regulated in a number of cancers cells and tissues.

POST-TRANSLATIONAL MODIFICATION

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.; N-glycosylated. N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.

SUBCELLULAR LOCATION

Endoplasmic reticulum. Nucleus. Secreted.

FUNCTION

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.