LXR beta Recombinant Rabbit Monoclonal Antibody [PSH0-56] (HA721403)

UNIPROT #

P55055

PROTEIN NAME

LXR beta

SYNONYMS

Liver X nuclear receptor beta antibody;Liver X receptor beta antibody;LX receptor beta antibody;LXR b antibody;LXR beta antibody;LXRB antibody;NER antibody;NER I antibody;NER1 antibody;NR1H 2 antibody;NR1H2 antibody;NR1H2_HUMAN antibody;Nuclear orphan receptor LXR beta antibody;Nuclear receptor NER antibody;Nuclear receptor subfamily 1 group H member 2 antibody;OR-1 antibody;Oxysterols receptor LXR-beta antibody;RIP15 antibody;Steroid hormone nuclear receptor NER antibody;Ubiquitously-expressed nuclear receptor antibody;UNR antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins. Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element. Liver X receptor beta has been shown to interact with NCOA6[8] and Retinoid X receptor alpha.