LY6A Recombinant Rabbit Monoclonal Antibody [JM53-11] (ET1703-67)

UNIPROT #

P05533

PROTEIN NAME

LY6A

SYNONYMS

Ly-6A.2/Ly-6E. antibody;Ly-6A.2/Ly-6E.1 antibody;Ly6a antibody;LY6A_MOUSE antibody;Ly6al antibody;Lymphocyte antigen 6A-2/6E-1 antibody;Lymphocyte antigen Ly 6A.2/Ly 6E.1 antibody;SCA-1 antibody;Stem cell antigen 1 antibody;T cell activating protein antibody;T-cell-activating protein antibody;TAP antibody

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated. Not N-glycosylated.; Not phosphorylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The Ly-6 alloantigens represent a family of phosphatidylinositol anchored proteins that play a role in the process of T lymphocyte activation. Ly-6 expression is commonly induced on T and B lymphocytes after activation by mitogens. Ly-6A/E is a phosphatidylinositol-linked transmembrane member of the Ly-6 family that is produced in humans after 4 weeks of age. γ-interferon and TNF regulate Ly-6A/E at the level of transcription and mRNA stabilization in certain thymocytes and T-cells.