Ly6c Rabbit Polyclonal Antibody (HA500088)
Catalog# HA500088
Rabbit Polyclonal to Ly6c
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WB
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IHC-P
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Mouse
Positive control:
Lane 1: Mouse lung tissue lysate
Lane 2: Mouse cerebellum tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Ly6c Rabbit Polyclonal Antibody (HA500088)
Immunogen
Synthetic peptide within mouse ly6c1 aa 75-100.
Host
Rabbit
Positive Control
Mouse lung tissue lysate, mouse cerebellum tissue lysate, mouse lung tissue, mouse brain tissue, mouse spleen tissue, mouse heart tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 14 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Ly6c
SYNONYMS
Ly 6c antibody;Ly6c protein antibody;Ly6c1 antibody;Ly6c2 antibody;Lymphocyte antigen 6 complex antibody;Lymphocyte antigen 6 complex locus C antibody;Lymphocyte antigen 6C antibody;Lymphocyte antigen 6C1 antibody;Lymphocyte antigen 6C2 antibody;Lymphocyte antigen Ly 6C antibody
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
The gene encoding the mouse alloantigen, Ly-6C, maps to chromosome 15 and encodes a 131 amino acid protein that belongs to the Ly-6 family of glycosyl-phosphatidylinositol (GPI)-linked proteins. Ly-6 family members share amino acid homology throughout a distinctive cysteine rich protein domain that incorporates O-linked carbohydrates. Murine Ly-6 molecules have unique patterns of tissue expression during hematopoiesis from multipotential stem cells to lineage committed precursor cells, and on specific leukocyte subpopulations in the peripheral lymphoid tissues. Ly-6C is predominantly expressed on murine peripheral CD8 T cells. Ly-6C is involved in endothelial adhesion, the killing of target cells by CTLs, inducing TCR-mediated activation of IL-2 and IFN-γ production in CD8 T cells and the homing of CD8 T cells. In addition, Ly-6C may act as a signaling molecule of LFA-1 activation.
CITATIONS
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Garcia-Flores, V., Romero, R., Peyvandipour, A., Galaz, J., Pusod, E., Panaitescu, B., Miller, D., Xu, Y., Tao, L., Liu, Z., Tarca, A. L., Pique-Regi, R., & Gomez-Lopez, N.
A single-cell atlas of murine reproductive tissues during preterm labor
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IF
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Mouse
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Citation
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