LYVE1 Recombinant Rabbit Monoclonal Antibody [JF0979] (ET1702-29)

UNIPROT #

Q9Y5Y7

PROTEIN NAME

LYVE1

SYNONYMS

Cell surface retention sequence-binding protein 1 antibody;CRSBP 1 antibody;CRSBP-1 antibody;CRSBP1 antibody;extracellular link domain containing 1 antibody;extracellular link domain-containing 1 antibody;Extracellular link domain-containing protein 1 antibody;HAR antibody;Hyaluronic acid receptor antibody;Lymphatic endothelium specific hyaluronan receptor antibody;lymphatic vessel endothelial hyaluronan receptor 1 antibody;Lymphatic vessel endothelial hyaluronic acid receptor 1 antibody;LYVE 1 antibody;LYVE-1 antibody;LYVE1 antibody;LYVE1_HUMAN antibody;XLKD1 antibody

TISSUE SPECIFICITY

Mainly expressed in endothelial cells lining lymphatic vessels.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation.