MAP1LC3A Recombinant Rabbit Monoclonal Antibody [SN07-40] (ET1611-37)

UNIPROT #

Q9H492

PROTEIN NAME

MAP1LC3A

SYNONYMS

ATG8E antibody;Autophagy-related protein LC3 A antibody;Autophagy-related ubiquitin-like modifier LC3 A antibody;LC3 antibody;LC3A antibody;MAP1 light chain 3 like protein 1 antibody;MAP1 light chain 3-like protein 1 antibody;MAP1A/1B light chain 3 A antibody;MAP1A/MAP1B LC3 A antibody;MAP1A/MAP1B light chain 3 A antibody;MAP1ALC3 antibody;MAP1BLC3 antibody;Map1lc3a antibody;Microtubule associated proteins 1A/1B light chain 3 antibody;Microtubule-associated protein 1 light chain 3 alpha antibody;Microtubule-associated proteins 1A and 1B, light chain 3 antibody;Microtubule-associated proteins 1A/1B light chain 3A antibody;MLP3A_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ATG8 family.

TISSUE SPECIFICITY

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

POST-TRANSLATIONAL MODIFICATION

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.

SUBCELLULAR LOCATION

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule.

FUNCTION

Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3β) and MAP-light chain 3 alpha (MAP-LC3α), both of which are mammalian homologs of yeast Apg8, are subunits that can associate with either MAP-1A or MAP-1B. While MAP-LC3β is essential for autophagy and is associated with autophagosome membranes after processing, MAP LC3α is involved in the formation of autophagosomal vacuoles and is localized to the intracytoplasmic membrane. MAP LC3α is expressed as two alternatively spliced isoforms that are expressed in testis, brain, heart, liver and skeletal muscle, but are absent in thymus and peripheral blood leukocytes.