MAVS Rabbit Polyclonal Antibody (HA500530)

UNIPROT #

Q7Z434

PROTEIN NAME

MAVS

SYNONYMS

CARD adapter inducing interferon beta antibody;CARD adaptor inducing IFN beta antibody;Cardif antibody;DKFZp666M015 antibody;FLJ27482 antibody;FLJ41962 antibody;IFN B promoter stimulator 1 antibody;Interferon beta promoter stimulator protein 1 antibody;Ips 1 antibody;IPS-1 antibody;Ips1 antibody;KIAA1271 antibody;MAVS antibody;MAVS_HUMAN antibody;Mitochondrial anti viral signaling protein antibody;Mitochondrial Antiviral Signaling antibody;Mitochondrial antiviral signaling protein antibody;Mitochondrial antiviral-signaling protein antibody;Putative NF kappa B activating protein 031N antibody;Putative NF-kappa-B-activating protein 031N antibody;Virus induced signaling adapter antibody;virus induced signaling adaptor antibody;Virus-induced-signaling adapter antibody;VISA antibody

SUBCELLULAR LOCATION

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome.

FUNCTION

Required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.