M-CSF Recombinant Rabbit Monoclonal Antibody [SU0413] (ET1609-1)

UNIPROT #

P09603

PROTEIN NAME

M-CSF

SYNONYMS

Colony stimulating factor 1 (macrophage) antibody;Colony stimulating factor 1 antibody;Colony stimulating factor macrophage specific antibody;CSF 1 antibody;CSF-1 antibody;CSF1 antibody;CSF1_HUMAN antibody;Csfm antibody;Lanimostim antibody;M CSF antibody;M-CSF antibody;Macrophage Colony Stimulating Factor 1 antibody;Macrophage colony stimulating factor antibody;MCSF antibody;MGC31930 antibody;Processed macrophage colony-stimulating factor 1 antibody

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.

SUBCELLULAR LOCATION

Membrane, Secreted, extracellular space, nuclear body.

FUNCTION

The macrophage colony-stimulating factor (M-CSF), also designated CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that can stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor cells. M-CSF is a homodimeric cytokine that is produced by fibroblasts, epithelial cells, bone marrow stromal cells, osteoblasts, keratinocytes, macrophages, T cells and B cells. M-CSF is a glycoprotein required for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF has also been identified as an important mediator of the inflammatory response and can regulate the release of proinflammatory cytokines from macrophages. M-CSF exerts its pleiotropic effects by binding to a single type of high affinity cell surface receptor that is encoded by the c-Fms proto-oncogene.