MED12 Rabbit Polyclonal Antibody (HA500331)

UNIPROT #

Q93074

PROTEIN NAME

MED12

SYNONYMS

Activator recruited cofactor 240 kDa component antibody;Activator-recruited cofactor 240 kDa component antibody;ARC240 antibody;CAG repeat protein 45 antibody;CAGH45 antibody;HOPA antibody;KIAA0192 antibody;MED12 antibody;MED12_HUMAN antibody;Mediator complex subunit 12 antibody;Mediator of RNA polymerase II transcription subunit 12 antibody;OPA containing protein antibody;OPA-containing protein antibody;Thyroid hormone receptor associated protein complex 230 kDa component antibody;Thyroid hormone receptor-associated protein complex 230 kDa component antibody;TNRC11 antibody;Trap230 antibody;Trinucleotide repeat containing gene 11 protein antibody;Trinucleotide repeat-containing gene 11 protein antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.