MEF2C Recombinant Rabbit Monoclonal Antibody [JE35-45] (HA721298)

UNIPROT #

Q06413

PROTEIN NAME

MEF2C

SYNONYMS

C5DELq14.3 antibody;DEL5q14.3 antibody;MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody;MADS box transcription enhancer factor 2, polypeptide C antibody;MEF2C antibody;MEF2C_HUMAN antibody;Myocyte enhancer factor 2C antibody;Myocyte specific enhancer factor 2C antibody;Myocyte-specific enhancer factor 2C antibody;OTTHUMP00000222409 antibody;Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus

FUNCTION

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architectur. Isoforms that lack the repressor domain are more active than isoform 1. Expressed in brain and skeletal muscle. Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease.