MELK Recombinant Rabbit Monoclonal Antibody [PSH03-55] (HA722014)

UNIPROT #

Q14680

PROTEIN NAME

MELK

SYNONYMS

AI327312 antibody;hMELK antibody;HPK 38 antibody;hPK38 antibody;KIAA0175 antibody;Likely ortholog of maternal embryonic leucine zipper kinase antibody;Maternal embryonic leucine zipper kinase antibody;MELK antibody;MELK_HUMAN antibody;mKIAA0175 antibody;MPK38 antibody;OTTHUMP00000021377 antibody;OTTHUMP00000046113 antibody;pEg3 kinase antibody;Protein kinase Eg3 antibody;Protein kinase PK38 antibody;RP23 382O11.1 antibody;Tyrosine protein kinase MELK antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition. MELK was previously believed to be essential for cancer cell proliferation. However, recent research using CRISPR has demonstrated that MELK is fully dispensable for cancer cell growth, casting doubt on the rationale for targeting this protein in patients. The results are dependent on the experimental design. Therefore, there is a need for further research. MELK has been shown to interact with CDC25B.