MHC Class II Recombinant Rabbit Monoclonal Antibody [JA10-94] (ET1704-13)

UNIPROT #

P04440

PROTEIN NAME

MHC Class II

SYNONYMS

D6S221E antibody;DMA antibody;DMB antibody;DP beta 1 antibody;DP beta 1 chain antibody;DP(W4) beta chain antibody;DPB 1 antibody;DPB1 antibody;DPB1_HUMAN antibody;DRB antibody;H2Ea antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DM beta chain antibody;HLA class II histocompatibility antigen, DP beta 1 chain antibody;HLA class II histocompatibility antigen, DP(W4) beta chain antibody;HLA DMB antibody;HLA DP1A antibody;HLA DPB1 antibody;HLA SB alpha chain antibody;HLA-A antibody;HLA-A histocompatibility type antibody;HLA-DP antibody;HLA-DP histocompatibility type, beta-1 subunit antibody;HLA-DP1B antibody;HLA-DPB antibody;HLA-DPB1 antibody;HLADM antibody;HLADP1B antibody;HLASB antibody;HLASB histocompatibility type antibody;Human MHC class II HLA SB alpha antibody;LA class II histocompatibility antigen DP alpha 1 chain antibody;Major histocompatibility complex class II antibody;Major histocompatibility complex class II DP alpha 1 antibody;Major histocompatibility complex class II DP beta 1 antibody;Major histocompatibility complex, class I, A antibody;MHC class II antigen DMB antibody;MHC class II antigen DPB1 antibody;MHC class II DP3 alpha antibody;MHC class II DPA1 antibody;MHC class II HLA-DP-beta-1 antibody;MHC DPB1 antibody;MHC HLA DPB1 antibody;PLT1 antibody;Primed lymphocyte test 1 antibody;RING6 antibody;RING7 antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class II family.

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum membrane.

FUNCTION

Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.