Mib1 Recombinant Rabbit Monoclonal Antibody [JG69-34] (ET7108-43)

UNIPROT #

Q86YT6

PROTEIN NAME

Mib1

SYNONYMS

DAPK-interacting protein 1 antibody;Dip 1 antibody;DIP-1 antibody;Dip1 antibody;E3 ubiquitin protein ligase MIB 1 antibody;E3 ubiquitin protein ligase MIB1 antibody;E3 ubiquitin-protein ligase mib1 antibody;KIAA1323 antibody;LVNC7 antibody;MIB antibody;mib1 antibody;MIB1_HUMAN antibody;Mind bomb homolog 1 antibody;Mindbomb E3 ubiquitin protein ligase 1 antibody;Ubiquitin ligase mind bomb antibody;Zinc finger ZZ type with ankyrin repeat domain protein 2 antibody;ZZANK2 antibody;ZZZ6 antibody

TISSUE SPECIFICITY

Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.

SUBCELLULAR LOCATION

Plasma membrane. Cytoplasm. Cytoskeleton.

FUNCTION

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.