MMP-1 Recombinant Rabbit Monoclonal Antibody [PSH09-56] (HA723118)

UNIPROT #

P03956

PROTEIN NAME

MMP-1

SYNONYMS

27 kDa interstitial collagenase antibody;CLG antibody;CLGN antibody;collagenase, fibroblast antibody;collagenase, interstitial antibody;Fibroblast collagenase antibody;Interstitial collagenase antibody;Matrix metallopeptidase 1 (interstitial collagenase) antibody;Matrix metalloprotease 1 antibody;Matrix Metalloproteinase 1 antibody;Matrix metalloproteinase-1 antibody;MMP 1 antibody;MMP-1 antibody;MMP1 antibody;MMP1_HUMAN antibody;OTTHUMP00000045866 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA. MMP-1 has an estimated molecular mass of 54 kDa. MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Specifically, MMP-1 breaks down the interstitial collagens, types I, II, and III.