MRP1 Recombinant Rabbit Monoclonal Antibody [JA93-03] (ET1704-56)

UNIPROT #

P33527

PROTEIN NAME

MRP1

SYNONYMS

ABC 29 antibody;ABC29 antibody;ABCC 1 antibody;ABCC antibody;Abcc1 antibody;ATP binding cassette sub family C (CFTR/MRP) member 1 antibody;ATP binding cassette sub-family C member 1 antibody;ATP binding cassette subfamily C member 1 antibody;ATP binding cassette transporter variant ABCC1delta ex13 antibody;ATP binding cassette transporter variant ABCC1delta ex13&14 antibody;ATP binding cassette transporter variant ABCC1delta ex25 antibody;ATP binding cassette transporter variant ABCC1delta ex25&26 antibody;ATP binding cassette, sub-family C (CFTR/MRP), member 1 antibody;ATP-binding cassette sub-family C member 1 antibody;DKFZp686N04233 antibody;DKFZp781G125 antibody;GS X antibody;GSX antibody;Leukotriene C(4) transporter antibody;LTC4 transporter antibody;MRP 1 antibody;MRP antibody;MRP1 antibody;MRP1_HUMAN antibody;Multidrug resistance associated protein 1 antibody;Multidrug resistance protein antibody;Multidrug resistance-associated protein 1 antibody;Multiple drug resistance associated protein antibody;Multiple drug resistance protein 1 antibody

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

TISSUE SPECIFICITY

Lung, testis and peripheral blood mononuclear cells.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an Mdr-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.