MSR1 Rabbit Polyclonal Antibody (ER1902-71)

UNIPROT #

P21757

PROTEIN NAME

MSR1

SYNONYMS

CD204 antibody;CD204 antigen antibody;CD24 antibody;Macrophage acetylated LDL receptor I and II antibody;Macrophage scavenger receptor 1 antibody;Macrophage scavenger receptor type III antibody;Macrophage scavenger receptor types I and II antibody;Msr 1 antibody;MSR1 antibody;MSRE_HUMAN antibody;phSR1 antibody;phSR2 antibody;SCARA 1 antibody;SCARA1 antibody;Scavenger receptor class A member 1 antibody;Scavenger receptor class A, member 1 antibody;Scavenger receptor type A antibody;Scvr antibody;SR A antibody;SRA antibody

TISSUE SPECIFICITY

Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.

SUBCELLULAR LOCATION

Membrane

FUNCTION

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. They were thought to be expressed macrophage-specific, but recently shown to be present on different dendritic cells classes, too. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.