STK4 / MST-1 Rabbit Polyclonal Antibody (HA500031)

UNIPROT #

Q13043

PROTEIN NAME

MST1

SYNONYMS

Kinase responsive to stress antibody;Krs2 antibody;Mammalian STE20 like protein kinase 1 antibody;Mammalian STE20-like protein kinase 1 antibody;Mammalian sterile 20 like 1 antibody;MST-1 antibody;MST1 antibody;Serine/threonine kinase 4 antibody;Serine/threonine protein kinase Krs 2 antibody;Serine/threonine-protein kinase 4 antibody;Serine/threonine-protein kinase Krs-2 antibody;STE20 like kinase MST1 antibody;STE20-like kinase MST1 antibody;STK4 antibody;STK4_HUMAN antibody;TIIAC antibody;YSK3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.