Mst2 Recombinant Rabbit Monoclonal Antibody [SC05-83] (ET1610-8)

UNIPROT #

Q13188

PROTEIN NAME

Mst2

SYNONYMS

DKFZp686A2068 antibody;FLJ90748 antibody;KRS1 antibody;KRS2 antibody;Mammalian STE20 like protein kinase 1 antibody;Mammalian STE20 like protein kinase 2 antibody;MST 1 antibody;MST 2 antibody;MST1 antibody;MST2 antibody;Serine/threonine kinase 3 (STE20 homolog yeast) antibody;Serine/threonine kinase 3 (Ste20 yeast homolog) antibody;Serine/threonine kinase 3 antibody;Serine/threonine kinase 4 antibody;Serine/threonine protein kinase 3 antibody;Serine/threonine protein kinase 4 antibody;Serine/threonine protein kinase Krs 1 antibody;Serine/threonine protein kinase Krs 2 antibody;STE20 like kinase MST1 antibody;STE20 like kinase MST2 antibody;STK 3 antibody;STK 4 antibody;STK3 antibody;STK4 antibody;YSK3 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

TISSUE SPECIFICITY

Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-117 and Thr-384 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF1.; Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N).

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Sterile-20 (Ste20) is a serine/threonine kinase in Saccharomyces cerevisiae that is involved in relaying signals from G protein-coupled receptors to cyto-solic MAP kinase cascades. Mammalian protein kinases that display sequence similarity to Ste20 are divided into two groups, the PAK subfamily and the GCK subfamily. The PAK subfamily members contain a C-terminal catalytic domain and an N-terminal regulatory domain with a p21Rac/Cdc42-binding site, and these kinases can activate both p38 MAPK and JNK. The GCK subfamily members contain a C-terminal regulatory domain and an N-terminal catalytic domain, and they have diverse roles in many pathways, including the activation of ERK, JNK, p38 MAPK, and caspase-3. The mammalian Ste20-like kinases (MST kinases), also known as Krs proteins, are members of the GCK subfamily. Ksr-1 (MST-2) and Ksr-2 (MST-1) are both direct substrates of caspase-3 that accelerate caspase-3 activation. MST-3 is ubiquitously expressed in mammalian tissue and can phosphorylate exogenous substrates as well as itself. MST-4 is highly expressed in placenta, thymus, and peripheral blood leukocytes, and it specifically activates ERK.