Myc tag Mouse Monoclonal Antibody [A3C8] (EM1902-38)
Catalog# EM1902-38
Mouse Monoclonal to Myc tag
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WB
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ELISA
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IP
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Species independent
Specifications
Product Type
Mouse monoclonal primary
Product Name
Myc tag Mouse Monoclonal Antibody [A3C8] (EM1902-38)
Immunogen
Synthetic peptide eqkliseedl conjugated to keyhole limpet haemocyanin.
Host
Mouse
Positive Control
C-terminal Myc-tagged recombinant protein lysates, N-terminal Myc-tagged recombinant protein lysates.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A3C8
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:5,000
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ELISA
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Use at an assay dependent concentration.
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IP
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2-5 µg/ml.
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2ug/ul
Purification
Protein A affinity purified.
Isotype
IgG1
TARGET
PROTEIN NAME
Myc tag
SYNONYMS
AU016757 antibody;Avian myelocytomatosis viral oncogene homolog antibody;bHLHe39 antibody;c Myc antibody;Cellular myelocytomatosis oncogene antibody;Class E basic helix-loop-helix protein 39 antibody;MGC105490 antibody;MRTL antibody;Myc antibody;Myc protein antibody;Myc proto oncogene protein antibody;Myc proto-oncogene protein antibody;myc-related translation/localization regulatory factor antibody;MYC_HUMAN antibody;Myc2 antibody;myca antibody;MYCC antibody;Myelocytomatosis oncogene a antibody;Myelocytomatosis oncogene antibody;Niard antibody;Nird antibody;oncogene c-Myc antibody;Oncogene Myc antibody;OTTHUMP00000158589 antibody;OTTHUMP00000227763 antibody;Proto-oncogene c-Myc antibody;Protooncogene homologous to myelocytomatosis virus antibody;RNCMYC antibody;Transcription factor p64 antibody;Transcriptional regulator Myc-A antibody;V-Myc avian myelocytomatosis viral oncogene homolog antibody;v-myc myelocytomatosis viral oncogene homolog (avian) antibody;zc-myc antibody
FUNCTION
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis . Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of elongation factors.[8] It can also act as a transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In addition, myc has a direct role in the control of DNA replication.[9] This activity could contribute to DNA amplification in cancer cells.
CITATIONS
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Shenyu Zhu,et al
Pulsatile Flow Increases METTL14-induced m6A Modification and Attenuates SepticCardiomyopathy: an experimental study
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ChIP
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Citation
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TALE-triggered and iTALE-suppressed Xa1-mediated resistance to bacterial blight is independent of rice transcription factor subunits OsTFIIAγ1 or OsTFIIAγ5
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co-IP
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rice
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Citation
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