MYH7B Recombinant Rabbit Monoclonal Antibody [JE54-44] (ET7110-69)

UNIPROT #

A7E2Y1

PROTEIN NAME

MYH7B

SYNONYMS

Antigen MLAA-21 antibody;cardiac muscle beta isoform antibody;Myh7b antibody;MYH7B_HUMAN antibody;Myosin cardiac muscle beta chain antibody;Myosin heavy chain 7B antibody;Myosin-7B antibody;Slow A MYH14 antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

TISSUE SPECIFICITY

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.

DEVELOPMENTAL STAGE

Found in fetal liver and brain.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.MYH7B is a slow-twitch myosin.The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined.