Myosin Light Chain 2 Recombinant Rabbit Monoclonal Antibody [SN67-09] (ET1611-13)

UNIPROT #

P10916

PROTEIN NAME

Myosin Light Chain 2

SYNONYMS

Cardiac myosin light chain-2 antibody;Cardiac ventricular myosin light chain 2 antibody;CMH10 antibody;MLC 2v antibody;MLC-2 antibody;MLC-2v antibody;MLC2 antibody;MLRV_HUMAN antibody;MYL 2 antibody;MYL2 antibody;Myosin light chain 2 regulatory cardiac slow antibody;Myosin light polypeptide 2 regulatory cardiac slow antibody;Myosin regulatory light chain 2 antibody;Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody;Regulatory light chain of myosin antibody;RLC of myosin antibody;Slow cardiac myosin regulatory light chain 2 antibody;ventricular/cardiac muscle isoform antibody

POST-TRANSLATIONAL MODIFICATION

N-terminus is methylated by METTL11A/NTM1.; Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7). Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v is a 19-KDa protein composed of 166 amino acids, that belongs to the EF-hand Ca2+ binding superfamily.[8] MLC-2v interacts with the neck/tail region of the muscle thick filament protein myosin to regulate myosin motility and function.