NC2 alpha Rabbit Polyclonal Antibody (HA500224)

UNIPROT #

Q14919

PROTEIN NAME

NC2 alpha

SYNONYMS

DR1 associated corepressor antibody;DR1 associated protein 1 (negative cofactor 2 alpha) antibody;DR1 associated protein 1 antibody;DR1 associated protein1 antibody;Dr1-associated corepressor antibody;Dr1-associated protein 1 antibody;DRAP 1 antibody;Drap1 antibody;NC 2 alpha antibody;NC 2alpha antibody;NC2 alpha antibody;NC2-alpha antibody;NC2A_HUMAN antibody;Negative co-factor 2-alpha antibody;Negative cofactor 2 alpha antibody;Negative cofactor 2alpha antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.