NFAT2 Recombinant Rabbit Monoclonal Antibody [JA81-03] (ET1704-45)

UNIPROT #

O95644

PROTEIN NAME

NFAT2

SYNONYMS

cytoplasmic 1 antibody;MGC138448 antibody;NF ATc antibody;NF ATc1 antibody;NF-ATc antibody;NF-ATc1 antibody;NF-ATc1.2 antibody;NFAC1_HUMAN antibody;NFAT 2 antibody;NFAT transcription complex cytosolic component antibody;NFATC 1 antibody;NFATc antibody;NFATc1 antibody;Nuclear factor of activated T cells cytoplasmic 1 antibody;Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1 antibody;Nuclear factor of activated T cells cytosolic component 1 antibody;nuclear factor of activated T-cells 'c' antibody;Nuclear factor of activated T-cells antibody

TISSUE SPECIFICITY

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.