NFIB / NF1B2 Mouse Monoclonal Antibody [1H5] (EM1701-69)

UNIPROT #

O00712

PROTEIN NAME

NFIB / NF1B2

SYNONYMS

CCAAT Box Binding Transcription Factor antibody;CCAAT-box-binding transcription factor antibody;CTF antibody;HMGIC/NFIB antibody;NF-I/B antibody;NF1-B antibody;NF1B antibody;NF1B2 antibody;NFI-B antibody;NFI-RED antibody;Nfib antibody;NFIB_HUMAN antibody;NFIB2 antibody;NFIB3 antibody;Nuclear factor 1 B-type antibody;Nuclear factor 1/B antibody;Nuclear Factor 1B antibody;Nuclear Factor I B antibody;Nuclear factor I/B antibody;TGGCA Binding Protein antibody;TGGCA-binding protein antibody;TRANSCRIPTION FACTOR NFIB antibody

SEQUENCE SIMILARITIES

Belongs to the CTF/NF-I family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.