NLK Rabbit Polyclonal Antibody (HA500033)

UNIPROT #

Q9UBE8

PROTEIN NAME

NLK

SYNONYMS

DKFZp761G1211 antibody;FLJ21033 antibody;LAK1 antibody;Nemo like kinase antibody;Nemo-like kinase antibody;Nlk antibody;NLK_HUMAN antibody;Protein LAK1 antibody;Serine/threonine protein kinase NLK antibody;Serine/threonine-protein kinase NLK antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Nlk Antibody (B-5) is a high quality monoclonal Nlk antibody (also designated Nlk antibody) suitable for the detection of the Nlk protein of mouse, rat and human origin. Nlk Antibody (B-5) is available as both the non-conjugated anti-Nlk antibody form, as well as multiple conjugated forms of anti-Nlk antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2 (1-4), respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both Thr 183 and Tyr 185 is required for full enzymatic activation. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Nlk, or nemo-like kinase, is a murine homolog of the Drosophila nemo (nmo) gene. Nlk and Nmo have sequence homology to both the ERK MAP kinases and the cyclin dependent kinases. Nlk is a nuclear protein with the ability to autophosphorylate.