NM23 Mouse Monoclonal Antibody [13C2] (EM1901-18)

UNIPROT #

P15531

PROTEIN NAME

NM23

SYNONYMS

AWD antibody;AWD, drosophila, homolog of antibody;GAAD antibody;Granzyme A activated DNase antibody;Granzyme A-activated DNase antibody;GZMA activated DNase antibody;Metastasis inhibition factor NM23 antibody;NB antibody;NBS antibody;NDK A antibody;NDKA antibody;NDKA_HUMAN antibody;NDP kinase A antibody;NDPK-A antibody;NDPKA antibody;NM23 antibody;NM23 long variant, included antibody;nm23-H1 antibody;NM23-M1 antibody;NM23H1B, included antibody;NME/NM23 nucleoside diphosphate kinase 1 antibody;Nme1 antibody;NME1-NME2 spliced read-through transcript, included antibody;Non-metastatic cells 1, protein (NM23A) expressed in antibody;Nonmetastatic cells 1, protein expressed in antibody;Nonmetastatic protein 23 antibody;Nonmetastatic protein 23, homolog 1 antibody;Nucleoside diphosphate kinase A antibody;Tumor metastatic process-associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the NDK family.

TISSUE SPECIFICITY

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.