Nogo Receptor Recombinant Rabbit Monoclonal Antibody [JE33-68] (HA722391)

UNIPROT #

Q9BZR6

PROTEIN NAME

Nogo Receptor

SYNONYMS

NgR antibody;Nogo 66 receptor antibody;Nogo receptor antibody;Nogor antibody;Reticulon 4 receptor antibody;Rtn4r antibody;UNQ330/PRO526 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane raft, Cell projection, dendrite, axon, Perikaryon.

FUNCTION

Reticulon 4 receptor (RTN4R) also known as Nogo-66 Receptor (NgR) or Nogo receptor 1 is a protein which in humans is encoded by the RTN4R gene. This gene encodes the receptor for reticulon 4, oligodendrocytemyelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. The Nogo-66 Receptor (NgR) is a high affinity binding receptor for a region of Nogo, a myelin associated protein that inhibits axon outgrowth. NgR was identified by Strittmatter and colleagues using an expression cloning strategy. NgR is implicated in neuronal plasticity and regeneration. Its relative importance in mediating myelin inhibition in vitro and in vivo is currently under intense investigation, since this protein might be a good drug target for treatment of various neurological conditions such as spinal cord injury and stroke.