NXF1 Recombinant Rabbit Monoclonal Antibody [JE40-63] (ET7109-12)

UNIPROT #

Q9UBU9

PROTEIN NAME

NXF1

SYNONYMS

DKFZp667O0311 antibody;DmNXF1 antibody;MEX67 antibody;MEX67, yeast, homolog of antibody;Mex67p antibody;mRNA export factor TAP antibody;Mvb1 antibody;Nuclear RNA export factor 1 antibody;Nuclear RNA export factor 1 homolog (S. cerevisiae) antibody;nxf 1 antibody;NXF1 antibody;NXF1_HUMAN antibody;Protein small bristles antibody;Sbr antibody;TAP antibody;Tip associating protein antibody;Tip-associated protein antibody;Tip-associating protein antibody

SEQUENCE SIMILARITIES

Belongs to the NXF family.

TISSUE SPECIFICITY

Expressed ubiquitously.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

The constitutive transport element (CTE) of type D retroviruses serves as a signal of nuclear export for unspliced viral RNAs. TAP (tip-associating protein, also known as NXF1) mediates the export of CTE-containing simian type D retroviral RNAs through binding directly to the CTE. TAP is associated with a recognized mRNA export pathway and is a member of the multigene family of NXF proteins. NXF proteins belong to an evolutionarily conserved family of proteins, which are characterized by a leucine-rich-repeat domain (LRR) followed by a region known as the nuclear transport factor 2 (NTF2)-like domain.