p15 INK4b Rabbit Polyclonal Antibody (ER1901-75)

UNIPROT #

P42772

PROTEIN NAME

p15 INK4b

SYNONYMS

CDK inhibitory protein antibody;CDK4B Inhibitor antibody;Cdkn2b antibody;CDN2B_HUMAN antibody;Cyclin dependent kinase 4 inhibitor B antibody;Cyclin Dependent Kinase Inhibitor 2B antibody;Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4 antibody;Cyclin dependent kinases 4 and 6 binding protein antibody;Cyclin-dependent kinase 4 inhibitor B antibody;INK4B antibody;MTS 2 antibody;MTS-2 antibody;MTS2 antibody;Multiple tumor suppressor 2 antibody;Multiple Tumor Supressor 2 antibody;OTTHUMP00000021154 antibody;OTTHUMP00000021155 antibody;p14 CDK inhibitor antibody;p14 INK4b antibody;p14-INK4b antibody;P15 antibody;p15 CDK inhibitor antibody;p15 inhibits CDK4 antibody;p15 INK4b antibody;p15-INK4b antibody;p15INK4B antibody;TP 15 antibody;TP15 antibody

SEQUENCE SIMILARITIES

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

TISSUE SPECIFICITY

Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

SUBCELLULAR LOCATION

Cytoplasm. Also found in the nucleus.

FUNCTION

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.