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p16INK4a Recombinant Rabbit Monoclonal Antibody [SU0702] (ET1608-62)

Price: Regular price $385.00

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Catalog# ET1608-62

Rabbit Monoclonal to p16INK4a

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

  • IP

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

p16INK4a Recombinant Rabbit Monoclonal Antibody [SU0702] (ET1608-62)

Immunogen

Synthetic peptide within human p16ink4a aa 107-156 / 156.

Host

Rabbit

Positive Control

293 cell lysate, SiHa cell lysate, HepG2, Hela, PC-3M, human colon carcinoma tissue, human cervical carcinoma tissue, human ovary carcinoma tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SU0702

RRID

AB_3069819

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:100-1:500

  • IF-Tissue

  • 1:100-1:500

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 16 kDa

Isotype

IgG

TARGET

UNIPROT #

P42771

PROTEIN NAME

p16INK4a

SYNONYMS

CCM2 antibody;CDK4 inhibitor p16 INK4 antibody;CDK4I antibody;CDKN2 antibody;CDKN2A antibody;Cell cycle negative regulator beta antibody;CMM2 antibody;Cyclin dependent kinase 4 inhibitor A antibody;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody;Cyclin Dependent Kinase Inhibitor 2A antibody;Cyclin dependent kinase inhibitor 2A isoform 4 antibody;Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody;Cyclin dependent kinase inhibitor p16 antibody;INK4 antibody;INK4A antibody;MLM antibody;MTS1 antibody;Multiple tumor suppressor 1 antibody;p14 antibody;p16 antibody;P16INK4 antibody;p16INK4a antibody;p19 antibody;p19Arf antibody;TP16 antibody

SEQUENCE SIMILARITIES

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

TISSUE SPECIFICITY

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation seems to increase interaction with CDK4.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during replication) in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer.

CITATIONS

  • Wang Ping,et al

    Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia

  • Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism

  • Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway

  • Dou, W., Xie, J., Chen, J., Zhou, J., Xu, Z., Wang, Z., & Zhu, Q.

    Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway

  • Yu, H., Yu, Q., Mi, Y., Wang, P., Jin, S., Xiao, L., Guo, Q., & Wu, Y.

    Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus

  • Resveratrol Pretreatment Improved Heart Recovery Ability of Hyperglycemic Bone Marrow Stem Cells Transplantation in Diabetic Myocardial Infarction by Down-Regulating MicroRNA-34a

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