P4HB Recombinant Rabbit Monoclonal Antibody [JE54-98] (ET7110-92)

UNIPROT #

P07237

PROTEIN NAME

P4HB

SYNONYMS

Cellular thyroid hormone binding protein antibody;Cellular thyroid hormone-binding protein antibody;Collagen prolyl 4 hydroxylase beta antibody;Disulphide Isomerase antibody;DSI antibody;EC 5.3.4.1 antibody;Endoplasmic reticulum resident protein 59 antibody;ER protein 59 antibody;ERBA2L antibody;ERp59 antibody;GIT antibody;Gltathione insulin transhydrogenase antibody;Glutathione insulin transhydrogenase antibody;P4HB antibody;P4Hbeta antibody;p55 antibody;PDI antibody;PDIA1 antibody;PDIA1_HUMAN antibody;PDIR antibody;PHDB antibody;PO4DB antibody;PO4HB antibody;Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1) antibody;Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit antibody;PROHB antibody;Prolyl 4 hydroxylase beta polypeptide antibody;Prolyl 4 hydroxylase beta subunit antibody;Prolyl 4 hydroxylase subunit beta antibody;Prolyl 4-hydroxylase subunit beta antibody;Protein disulfide isomerase associated 1 antibody;Protein disulfide isomerase, family A, member 1 antibody;Protein disulfide isomerase/oxidoreductase antibody;Protein disulfide-isomerase antibody;Protocollagen hydroxylase antibody;Thbp antibody;Thyroid hormone binding protein p55 antibody;Thyroid hormone binding protein p55 cellular antibody;V erb a avian erythroblastic leukemia viral oncogene homolog 2 like antibody

SEQUENCE SIMILARITIES

Belongs to the protein disulfide isomerase family.

SUBCELLULAR LOCATION

Endoplasmic reticulum, endoplasmic reticulum lumen, cell membrane, melanosome.

FUNCTION

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.