p63 Recombinant Rabbit Monoclonal Antibody [JE53-53] (ET7110-47)

UNIPROT #

Q9H3D4

PROTEIN NAME

p63

SYNONYMS

AIS antibody;Amplified in squamous cell carcinoma antibody;B(p51A) antibody;B(p51B) antibody;Chronic ulcerative stomatitis protein antibody;CUSP antibody;DN p63 alpha 1 antibody;DNp63 antibody;EEC3 antibody;id:ibd3516 antibody;Keratinocyte transcription factor antibody;Keratinocyte transcription factor KET antibody;KET antibody;LMS antibody;MGC115972 antibody;MGC192897 antibody;NBP antibody;OFC8 antibody;OTTHUMP00000209732 antibody;OTTHUMP00000209733 antibody;OTTHUMP00000209734 antibody;OTTHUMP00000209735 antibody;OTTHUMP00000209737 antibody;OTTHUMP00000209738 antibody;OTTHUMP00000209739 antibody;OTTHUMP00000209740 antibody;OTTHUMP00000209741 antibody;OTTHUMP00000209742 antibody;OTTHUMP00000209743 antibody;OTTHUMP00000209744 antibody;p40 antibody;p51 antibody;P51/P63 antibody;p53-related protein p63 antibody;p53CP antibody;p63 antibody;P63_HUMAN antibody;p73H antibody;p73L antibody;RHS antibody;SHFM4 antibody;TAp63alpha antibody;TP53CP antibody;TP53L antibody;TP63 antibody;TP73L antibody;Transformation related protein 63 antibody;Transformation-related protein 63 antibody;Trp53rp1 antibody;Trp63 antibody;Tumor protein 63 antibody;Tumor protein p53-competing protein antibody;Tumor protein p53-like antibody;Tumor protein p63 antibody;Tumor protein p63 deltaN isoform delta antibody;Tumor protein p73 antibody;Tumor protein p73-like antibody

SEQUENCE SIMILARITIES

Belongs to the p53 family.

TISSUE SPECIFICITY

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

POST-TRANSLATIONAL MODIFICATION

May be sumoylated.; Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.