P63 Rabbit Polyclonal Antibody (R1311-3)

UNIPROT #

Q9H3D4

PROTEIN NAME

P63

SYNONYMS

AIS antibody;Amplified in squamous cell carcinoma antibody;B(p51A) antibody;B(p51B) antibody;Chronic ulcerative stomatitis protein antibody;CUSP antibody;DN p63 alpha 1 antibody;DNp63 antibody;EEC3 antibody;id:ibd3516 antibody;Keratinocyte transcription factor antibody;Keratinocyte transcription factor KET antibody;KET antibody;LMS antibody;MGC115972 antibody;MGC192897 antibody;NBP antibody;OFC8 antibody;OTTHUMP00000209732 antibody;OTTHUMP00000209733 antibody;OTTHUMP00000209734 antibody;OTTHUMP00000209735 antibody;OTTHUMP00000209737 antibody;OTTHUMP00000209738 antibody;OTTHUMP00000209739 antibody;OTTHUMP00000209740 antibody;OTTHUMP00000209741 antibody;OTTHUMP00000209742 antibody;OTTHUMP00000209743 antibody;OTTHUMP00000209744 antibody;p40 antibody;p51 antibody;P51/P63 antibody;p53-related protein p63 antibody;p53CP antibody;p63 antibody;P63_HUMAN antibody;p73H antibody;p73L antibody;RHS antibody;SHFM4 antibody;TAp63alpha antibody;TP53CP antibody;TP53L antibody;TP63 antibody;TP73L antibody;Transformation related protein 63 antibody;Transformation-related protein 63 antibody;Trp53rp1 antibody;Trp63 antibody;Tumor protein 63 antibody;Tumor protein p53-competing protein antibody;Tumor protein p53-like antibody;Tumor protein p63 antibody;Tumor protein p63 deltaN isoform delta antibody;Tumor protein p73 antibody;Tumor protein p73-like antibody

SEQUENCE SIMILARITIES

Belongs to the p53 family.

TISSUE SPECIFICITY

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

POST-TRANSLATIONAL MODIFICATION

May be sumoylated.; Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Tumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. TP63 mutations underlie several malformation syndromes that include cleft lip and/or palate as a hallmark feature. p63 immunostaining has utility for head and neck squamous cell carcinomas, differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue; normal prostatic glands stain with p63 (as they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not. P63 is also helpful in distinguishing poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma.