PCBP2 Recombinant Rabbit Monoclonal Antibody [JE65-05] (HA721109)

UNIPROT #

Q15366

PROTEIN NAME

PCBP2

SYNONYMS

Alpha CP2 antibody;Alpha-CP2 antibody;alphaCP-2 antibody;Cbp antibody;CTBP antibody;Heterogeneous nuclear ribonucleoprotein E2 antibody;Heterogenous nuclear ribonucleoprotein E2 antibody;hnRNP E2 antibody;hnRNP-E2 antibody;HNRNPE2 antibody;Hnrnpx antibody;HNRPE2 antibody;Hnrpx antibody;MGC110998 antibody;PCBP2 antibody;PCBP2_HUMAN antibody;poly(rC) binding protein 2 antibody;Poly(rC)-binding protein 2 antibody;Putative heterogeneous nuclear ribonucleoprotein X antibody;rCbinding protein 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.