PD-L2 Mouse Monoclonal Antibody [A10D8] (HA601331)

UNIPROT #

Q9BQ51

PROTEIN NAME

PD-L2

SYNONYMS

B7 dendritic cell molecule antibody;B7-DC antibody;B7DC antibody;bA574F11.2 antibody;Btdc antibody;Butyrophilin B7 DC antibody;Butyrophilin B7-DC antibody;Butyrophilin B7DC antibody;CD 273 antibody;CD273 antibody;CD273 antigen antibody;MGC142238 antibody;MGC142240 antibody;PD 1 ligand 2 antibody;PD L2 antibody;PD-1 ligand 2 antibody;PD-L2 antibody;PD1 ligand 2 antibody;PD1L2_HUMAN antibody;PDCD 1 ligand 2 antibody;PDCD1 ligand 2 antibody;PDCD1L2 antibody;Pdcd1lg2 antibody;PDL 2 antibody;PDL2 antibody;Programmed cell death 1 ligand 2 antibody;Programmed death ligand 2 antibody

SUBCELLULAR LOCATION

Secreted; Endomembrane system; Cell membrane.

FUNCTION

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-L2 binds to its receptor PD-1 with dissociation constant Kd of 11.3 nM. Binding to PD-1 can activate pathways inhibiting TCR/BCR-mediated immune cell activation (for a more detailed discussion see PD-1 signaling). PD-L2 plays an important role in immune tolerance and autoimmunity. Both PD-L1 and PD-L2 can inhibit T cell proliferation and inflammatory cytokine production. Blocking PD-L2 has been shown to exacerbate experimental autoimmune encephalomyelitis. Unlike PD-L1, PD-L2 has been shown activate the immune system. PD-L2 triggers IL-12 production in murine dendritic cells leading to T cell activation. Others have shown that treatment with PD-L2 Ig led to T helper cell proliferation.