PDE4D Mouse Monoclonal Antibody [A7F3] (HA601001)

UNIPROT #

Q08499

PROTEIN NAME

PDE4D

SYNONYMS

cAMP specific 3',5' cyclic phosphodiesterase 4D antibody;DKFZp686M11213 antibody;5''-cyclic phosphodiesterase 4D antibody;cAMP specific phosphodiesterase 4D antibody;cAMP specific phosphodiesterase PDE4D6 antibody;cAMP-specific 3'' antibody;DPDE3 antibody;Dunce like phosphodiesterase E3 antibody;FLJ97311 antibody;HSPDE4D antibody;PDE43 antibody;Pde4d antibody;PDE4D_HUMAN antibody;PDE4DN2 antibody;Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody;Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody;Phosphodiesterase 4D cAMP specific antibody;Phosphodiesterase 4D, cAMP specific (dunce) antibody;STRK1 antibody

SUBCELLULAR LOCATION

Apical cell membrane, Cytoplasm, Cytoskeleton, Centrosome, Membrane.

FUNCTION

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells. PDE4D has been shown to interact with myomegalin and GNB2L1. Mutations in this gene have been associated to cases of acrodysostosis. This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors. Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker.