PDK1 Recombinant Rabbit Monoclonal Antibody [JA67-30] (ET1704-66)

UNIPROT #

Q15118

PROTEIN NAME

PDK1

SYNONYMS

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial antibody;HGNC:8809 antibody;Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1 antibody;PDH kinase 1 antibody;Pdk1 antibody;PDK1_HUMAN antibody;Pyruvate dehydrogenase kinase isoform 1 antibody;Pyruvate dehydrogenase kinase, isoenzyme 1 antibody

SEQUENCE SIMILARITIES

Belongs to the PDK/BCKDK protein kinase family.

TISSUE SPECIFICITY

Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect.

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

Mitochondrial pyruvate dehydrogenase (PDH) catalyzes the oxidative decarboxylation of pyruvate and plays a central role in the regulation of homeostasis of carbohydrate fuels in mammals. PDH activity is controlled by a phosphorylation/dephosphorylation cycle, phosphorylation leading to inactivation and dephosphorylation leading to reactivation of PDH. The phosphorylation of PDH is catalyzed by pyruvate dehydrogenase kinase (PDK), the activity of which is stimulated by the products of PDH catalysis. PDK1 consists of alpha and beta subunits; the kinase activity resides in the alpha subunit. Three PDK isoenzymes have been identified in humans (PDK1, 2 and 3) and two have been identified in rodent (PDK1 and 2).