PER3 Rabbit Polyclonal Antibody (HA500072)

UNIPROT #

P56645

PROTEIN NAME

PER3

SYNONYMS

2810049O06Rik antibody;Cell growth inhibiting gene 13 protein antibody;Cell growth-inhibiting gene 13 protein antibody;Circadian clock protein PERIOD 3 antibody;GIG13 antibody;gPER3 antibody;Growth inhibiting protein 13 antibody;HGNC:8847 antibody;hPER3 antibody;mPer3 antibody;Per3 antibody;PER3_HUMAN antibody;Period 3 antibody;Period circadian clock 3 antibody;Period circadian protein 3 antibody;Period circadian protein homolog 3 antibody;Period homolog 3 (Drosophila) antibody;Period homolog 3 antibody;Period homolog 3, Drosophila antibody;Period3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms. A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes, harboring E-box elements within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression.