PERK Recombinant Rabbit Monoclonal Antibody [PSH0-81] (HA721510)

UNIPROT #

Q9NZJ5

PROTEIN NAME

PERK

SYNONYMS

DKFZp781H1925 antibody;E2AK3_HUMAN antibody;EC 2.7.11.1 antibody;Eif2ak3 antibody;Eukaryotic translation initiation factor 2 alpha kinase 3 antibody;Eukaryotic translation initiation factor 2-alpha kinase 3 antibody;Heme regulated EIF2 alpha kinase antibody;HRI antibody;HsPEK antibody;Pancreatic eIF2 alpha kinase antibody;Pancreatic eIF2-alpha kinase antibody;PEK antibody;PRKR like endoplasmic reticulum kinase antibody;PRKR-like endoplasmic reticulum kinase antibody;WRS antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Patients with mutations in this gene develop Wolcott-Rallison syndrome. EIF2AK3 has been shown to interact with DNAJC3, NFE2L2, and endoplasmic reticulum chaperone BiP (Hsp70).