PF4 Recombinant Rabbit Monoclonal Antibody [JE31-48] (HA721584)

UNIPROT #

P02776

PROTEIN NAME

PF4

SYNONYMS

C-X-C motif chemokine 4 antibody;Chemokine (C X C motif) ligand 4 antibody;Chemokine (CXC motif) ligand 4 antibody;chemokine ligand 4 antibody;CXCL 4 antibody;CXCL4 antibody;Iroplact antibody;MGC138298 antibody;Oncostatin A antibody;Oncostatin-A antibody;OncostatinA antibody;PF 4 antibody;PF-4 antibody;PF4 antibody;Pf4a antibody;Platelet factor 4 antibody;PLF4_HUMAN antibody;SCYB 4 antibody;SCYB4 antibody;short form antibody;Small inducible cytokine subfamily B antibody;Small inducible cytokine subfamily member 4 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan. The gene for human PF4 is located on human chromosome 4. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3-B.