Phospho-B Raf (T401) Recombinant Rabbit Monoclonal Antibody [JJ08-72] (ET1701-20)

UNIPROT #

P15056

PROTEIN NAME

Phospho-B Raf (T401)

SYNONYMS

FLJ95109 antibody;94 kDa B raf protein antibody;B raf 1 antibody;B Raf proto oncogene serine threonine protein kinase antibody;B Raf proto oncogene, serine/threonine kinase antibody;B RAF1 antibody;B-Raf proto-oncogene serine/threonine-protein kinase (p94) antibody;BRAF 1 antibody;BRAF antibody;BRAF_HUMAN antibody;BRAF1 antibody;cRmil antibody;MGC126806 antibody;MGC138284 antibody;Murine sarcoma viral (v-raf) oncogene homolog B1 antibody;Murine sarcoma viral v raf oncogene homolog B1 antibody;NS7 antibody;Oncogen BRAF antibody;oncogene BRAF1 antibody;p94 antibody;Proto-oncogene B-Raf antibody;Proto-oncogene c-Rmil antibody;RAFB 1 antibody;RAFB1 antibody;RMIL antibody;Serine/threonine-protein kinase B-raf antibody;v raf murine sarcoma viral oncogene homolog B antibody;v raf murine sarcoma viral oncogene homolog B1 antibody;v-Raf murine sarcoma viral oncogene homolog B1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

TISSUE SPECIFICITY

Brain and testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-365 by SGK1 inhibits its activity.; Methylation at Arg-671 decreases stability and kinase activity.; Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Cell membrane.

FUNCTION

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf. B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The B-Raf protein is involved in sending signals inside cells which are involved in directing cell growth. Certain other inherited BRAF mutations cause birth defects. Drugs that treat cancers driven by BRAF mutations have been developed. Two of these drugs, vemurafenib and dabrafenib are approved by FDA for treatment of late-stage melanoma.