Phospho-Beta Catenin (S33/S37) Recombinant Rabbit Monoclonal Antibody [JE59-59] (HA721580)

UNIPROT #

P35222

PROTEIN NAME

Phospho-Beta Catenin (S33/S37)

SYNONYMS

b-catenin antibody;Beta catenin antibody;Beta-catenin antibody;Cadherin associated protein antibody;Catenin (cadherin associated protein), beta 1, 88kDa antibody;Catenin beta 1 antibody;Catenin beta-1 antibody;CATNB antibody;CHBCAT antibody;CTNB1_HUMAN antibody;CTNNB antibody;CTNNB1 antibody;DKFZp686D02253 antibody;FLJ25606 antibody;FLJ37923 antibody;OTTHUMP00000162082 antibody;OTTHUMP00000165222 antibody;OTTHUMP00000165223 antibody;OTTHUMP00000209288 antibody;OTTHUMP00000209289 antibody

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).