Phospho-CaMKII (T286) Recombinant Rabbit Monoclonal Antibody [JE51-81] (HA721794)

UNIPROT #

Q13554

PROTEIN NAME

Phospho-CaMKII (T286)

SYNONYMS

Calcium/calmodulin dependent protein kinase II alpha antibody;Calcium/calmodulin dependent protein kinase II beta antibody;Calcium/calmodulin dependent protein kinase II delta antibody;Calcium/calmodulin dependent protein kinase II gamma antibody;Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody;CaM kinase II alpha antibody;CaM kinase II antibody;CaM kinase II beta antibody;CaM kinase II delta antibody;CaM kinase II gamma antibody;CaM kinase II subunit alpha antibody;CaMK-II subunit alpha antibody;CAMK2 antibody;Camk2a antibody;CAMK2B antibody;CAMK2D antibody;CAMK2G antibody;CAMKA antibody;KCC2A_HUMAN antibody

SUBCELLULAR LOCATION

Synapse, Postsynaptic density, Cell projection, dendritic spine, dendrite.

FUNCTION

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/ threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β,γandδ, which may or may not be coexpressed in the same tissue types. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.