phospho-Chk1 (S345) Recombinant Rabbit Monoclonal Antibody [PS01-17] (HA721189)

UNIPROT #

O14757

PROTEIN NAME

phospho-Chk1 (S345)

SYNONYMS

C85740 antibody;Cell cycle checkpoint kinase antibody;Checkpoint , S. pombe, homolog of, 1 antibody;Checkpoint kinase 1 antibody;Checkpoint kinase 1 homolog (S. pombe) antibody;CHEK 1 antibody;Chek1 antibody;Chk 1 antibody;Chk1 antibody;CHK1 checkpoint homolog (S. pombe) antibody;CHK1_HUMAN antibody;EC 2.7.11.1 antibody;rad27 antibody;Serine/threonine protein kinase Chk1 antibody;Serine/threonine-protein kinase CHK1 antibody;STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) antibody

SUBCELLULAR LOCATION

Nucleus, Chromosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

FUNCTION

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle. Checkpoint kinases (Chks) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, egg production, embryo development, cellular responses to HIV infection and somatic cell viability.