Phospho-eIF4E (S209) Recombinant Rabbit Monoclonal Antibody [SU0396] (ET1608-66)

UNIPROT #

P06730

PROTEIN NAME

Phospho-eIF4E (S209)

SYNONYMS

AUTS19 antibody;CBP antibody;eIF 4E antibody;eIF 4F 25 kDa subunit antibody;EIF 4F antibody;eIF-4E antibody;eIF-4F 25 kDa subunit antibody;eIF4E antibody;EIF4E1 antibody;EIF4EL1 antibody;EIF4F antibody;Eukaryotic translation initiation factor 4 E antibody;Eukaryotic translation initiation factor 4E antibody;Eukaryotic translation initiation factor 4E like 1 antibody;IF4E_HUMAN antibody;Messanger RNA Cap Binding Protein eIF 4E antibody;MGC111573 antibody;mRNA cap binding protein antibody;mRNA cap-binding protein antibody

SEQUENCE SIMILARITIES

Belongs to the eukaryotic initiation factor 4E family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm.Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap.Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis.In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation.May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development.