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Phospho--ErbB3/HER3 (Y1289) Recombinant Rabbit Monoclonal Antibody [JE51-25] (HA722178)

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Catalog# HA722178

Rabbit Monoclonal to Phospho--ErbB3/HER3 (Y1289)

Tested for

  • WB

  • IF-Cell

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Phospho--ErbB3/HER3 (Y1289) Recombinant Rabbit Monoclonal Antibody [JE51-25] (HA722178)

Immunogen

Synthetic phosphopeptide corresponding to a region surrounding tyr1289 of human erbb3.

Host

Rabbit

Modification

Phospho-

Modification Site

Y1289

Positive Control

MCF7 serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes cell lysate, MCF7 cells serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JE51-25

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 148 kDa

Isotype

IgG

TARGET

UNIPROT #

P21860

PROTEIN NAME

Phospho--ErbB3/HER3 (Y1289)

SYNONYMS

c erbB 3 antibody;c erbB3 antibody;Erb b2 receptor tyrosine kinase 3 antibody;ErbB 3 antibody;ERBB3 antibody;ERBB3 protein antibody;erbB3 S antibody;ERBB3_HUMAN antibody;Glial growth factor receptor antibody;HER 3 antibody;HER3 antibody;Human epidermal growth factor receptor 3 antibody;LCCS2 antibody;MDA BF 1 antibody;MGC88033 antibody;p180 ErbB3 antibody;p45 sErbB3 antibody;p85 sErbB3 antibody;proto-oncogene-like protein c ErbB 3 antibody;proto-oncogene-like protein c ErbB3 antibody;Proto-oncogene-like protein c-ErbB-3 antibody;Receptor tyrosine protein kinase erbB 3 antibody;Receptor tyrosine protein kinase erbB3 antibody;Receptor tyrosine-protein kinase erbB-3 antibody;Tyrosine kinase type cell surface receptor HER3 antibody;Tyrosine kinase-type cell surface receptor HER3 antibody;v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody;v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

SUBCELLULAR LOCATION

Cell membrane, secreted.

FUNCTION

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

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