PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] (HA721706)

UNIPROT #

Q13492

PROTEIN NAME

PICALM

SYNONYMS

CALM antibody;Clathrin assembly lymphoid myeloid leukemia antibody;Clathrin assembly lymphoid myeloid leukemia protein antibody;CLTH antibody;LAP antibody;Phosphatidylinositol-binding clathrin assembly protein antibody;PICAL_HUMAN antibody;PICALM antibody

SUBCELLULAR LOCATION

Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

FUNCTION

Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).