PKN2 Recombinant Rabbit Monoclonal Antibody [JE62-44] (HA720102)

UNIPROT #

Q16513

PROTEIN NAME

PKN2

SYNONYMS

Cardiolipin activated protein kinase Pak2 antibody;MGC150606 antibody;MGC71074 antibody;PAK 2 antibody;PAK2 antibody;PKN gamma antibody;PKN2 antibody;PKN2_HUMAN antibody;PRK2 antibody;PRKCL2 antibody;PRO2042 antibody;Protein kinase C like 2 antibody;Protein kinase C related kinase 2 antibody;Protein kinase C-like 2 antibody;Protein kinase N2 antibody;Protein-kinase C-related kinase 2 antibody;Serine/threonine-protein kinase N2 antibody

SUBCELLULAR LOCATION

Cytoskeleton, Nucleus, Cytoplasm, Membrane, lamellipodium, Cleavage furrow, Midbody, Cell junction.

FUNCTION

PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis.