PP2A(alpha+beta) Mouse Monoclonal Antibody [A0-G7] (M1603-4)

UNIPROT #

P62714

PROTEIN NAME

PP2A(alpha+beta)

SYNONYMS

PP2A A antibody;PP2A alpha antibody;PP2A B antibody;PP2A beta antibody;PP2A-alpha antibody;PP2AA_HUMAN antibody;PP2Ac antibody;PP2CB antibody;PPP2CA antibody;PPP2CB antibody;Protein phosphatase 2 catalytic subunit alpha isoform antibody;Protein phosphatase 2 catalytic subunit beta isoform antibody;Replication protein C antibody;RP C antibody;RP-C antibody;Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody;Serine/threonine protein phosphatase 2A catalytic subunit beta isoform antibody;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody

SEQUENCE SIMILARITIES

Belongs to the PPP phosphatase family. PP-1 subfamily.

POST-TRANSLATIONAL MODIFICATION

Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.; Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.; May be monoubiquitinated by NOSIP.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.